Understanding microRNAs in neurodegeneration
Identifieur interne : 000919 ( Main/Exploration ); précédent : 000918; suivant : 000920Understanding microRNAs in neurodegeneration
Auteurs : Stephen M. Eacker [États-Unis] ; Ted M. Dawson [États-Unis] ; Valina L. Dawson [États-Unis]Source :
- Nature Reviews Neuroscience [ 1471-003X ] ; 2009-12.
Abstract
Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.
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DOI: 10.1038/nrn2726
Affiliations:
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Dawson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BA7CA0C4F1C8EB169DB6CA6A5D1F088F3FEB8F03</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1038/nrn2726</idno><idno type="url">https://api.istex.fr/document/BA7CA0C4F1C8EB169DB6CA6A5D1F088F3FEB8F03/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002159</idno><idno type="wicri:Area/Main/Curation">001E51</idno><idno type="wicri:Area/Main/Exploration">000919</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Understanding microRNAs in neurodegeneration</title><author><name sortKey="Eacker, Stephen M" sort="Eacker, Stephen M" uniqKey="Eacker S" first="Stephen M." last="Eacker">Stephen M. Eacker</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Stephen M. Eacker, Ted M. Dawson and Valina L. Dawson are at the Neuroregeneration and Stem Cell Programs, the Institute for Cell Engineering and the Department of Neurology at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205</wicri:regionArea><wicri:noRegion>Maryland 21205</wicri:noRegion></affiliation></author><author><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M." last="Dawson">Ted M. Dawson</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Stephen M. Eacker, Ted M. Dawson and Valina L. Dawson are at the Neuroregeneration and Stem Cell Programs, the Institute for Cell Engineering and the Department of Neurology at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205</wicri:regionArea><wicri:noRegion>Maryland 21205</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Ted M. Dawson and Valina L. Dawson are also at the Department of Neuroscience at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205</wicri:regionArea><wicri:noRegion>Maryland 21205</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Dawson, Valina L" sort="Dawson, Valina L" uniqKey="Dawson V" first="Valina L." last="Dawson">Valina L. Dawson</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Stephen M. Eacker, Ted M. Dawson and Valina L. Dawson are at the Neuroregeneration and Stem Cell Programs, the Institute for Cell Engineering and the Department of Neurology at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205</wicri:regionArea><wicri:noRegion>Maryland 21205</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Ted M. Dawson and Valina L. Dawson are also at the Department of Neuroscience at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205</wicri:regionArea><wicri:noRegion>Maryland 21205</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Valina L. Dawson is also at the Department of Physiology at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205</wicri:regionArea><wicri:noRegion>Maryland 21205</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Nature Reviews Neuroscience</title><idno type="ISSN">1471-003X</idno><idno type="eISSN">1471-0048</idno><imprint><publisher>Nature Publishing Group</publisher><date type="published" when="2009-12">2009-12</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="837">837</biblScope><biblScope unit="page" to="841">841</biblScope></imprint><idno type="ISSN">1471-003X</idno></series><idno type="istex">BA7CA0C4F1C8EB169DB6CA6A5D1F088F3FEB8F03</idno><idno type="DOI">10.1038/nrn2726</idno><idno type="ArticleID">nrn2726</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1471-003X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Eacker, Stephen M" sort="Eacker, Stephen M" uniqKey="Eacker S" first="Stephen M." last="Eacker">Stephen M. Eacker</name></noRegion><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M." last="Dawson">Ted M. Dawson</name><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M." last="Dawson">Ted M. Dawson</name><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M." last="Dawson">Ted M. 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